St. Barnabus High School in the north Bronx said the decision was made "with a heavy heart."
"Despite such a beautiful and successful celebration of our 100th anniversary, our school is unable to overcome the financial strain it has been under for many years," the school said in announcing the news. "Enrollment levels over the past several years have challenged our ability to meet the costs of providing a quality curriculum.
"In addition, the rising costs of operating the building we have called home since 1959 has led to the very painful decision to cease operations."
The all-girls school, located off the Bronx River Parkway at East 240th Street, said it is doing "everything we can to make this difficult transition go as smoothly as possible for each of you."
Click here to follow Daily Voice Yonkers and receive free news updates.